Intrinsic macrolide resistance of the Mycobacterium tuberculosis complex is inducible.
نویسندگان
چکیده
Mycobacterium tuberculosis is intrinsically resistant to macrolides, a characteristic associated with expression of the erm(37) gene. This intrinsic resistance was found to be inducible with clarithromycin and the ketolide HMR3004. Furthermore, underlying the phenotypic induction was an increase in erm(37) mRNA levels.
منابع مشابه
Molecular basis of intrinsic macrolide resistance in the Mycobacterium tuberculosis complex.
The intrinsic resistance of the Mycobacterium tuberculosis complex (MTC) to most antibiotics, including macrolides, is generally attributed to the low permeability of the mycobacterial cell wall. However, nontuberculous mycobacteria (NTM) are much more sensitive to macrolides than members of the MTC. A search for macrolide resistance determinants within the genome of M. tuberculosis revealed th...
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 50 7 شماره
صفحات -
تاریخ انتشار 2006